Assay Detail
Binding
CHEMBL3425010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.57 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346178 | OSANETANT | 2.0 | 1 | 7.10 |
| CHEMBL3422009 | — | — | 1 | 6.10 |
| CHEMBL10188 | TALNETANT | 2.0 | 1 | 5.40 |
| CHEMBL3422015 | — | — | 1 | 5.00 |
| CHEMBL3422010 | — | — | 1 | 4.90 |
| CHEMBL3422018 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346178 | OSANETANT | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL3422009 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL10188 | TALNETANT | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL3422015 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL3422010 | — | Ki | = | 12589.25 | nM | 4.90 |
| CHEMBL3422018 | — | Ki | = | 12589.25 | nM | 4.90 |