Assay Detail
Functional
CHEMBL3427889
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Cytotoxicity against dog OSW cells assessed as cell death after 72 hrs by sulforhodamine B assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.02 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3426440 | — | — | 1 | 5.07 |
| CHEMBL3426407 | — | — | 1 | 5.03 |
| CHEMBL3426431 | — | — | 1 | 5.02 |
| CHEMBL3426403 | — | — | 1 | 5.01 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 5.00 |
| CHEMBL3426429 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3426440 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL3426407 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL3426431 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL3426403 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL591429 | PAC-1 | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3426429 | — | IC50 | = | 10000.0 | nM | 5.00 |