Assay Detail
Binding
CHEMBL3428032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ALR1 in calf kidney using sodium D-glucoronate as substrate treated with compound for 10 mins prior to substrate addition by UV spectrophotometer analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Kidney |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL3081) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Synthesis, characterization, hypoglycemic and aldose reductase inhibition activity of arylsulfonylspiro[fluorene-9,5'-imidazolidine]-2',4'-diones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.90 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3426173 | — | — | 1 | 5.46 |
| CHEMBL3426170 | — | — | 1 | 5.29 |
| CHEMBL3426177 | — | — | 1 | 5.06 |
| CHEMBL3426179 | — | — | 1 | 4.94 |
| CHEMBL3426178 | — | — | 1 | 4.92 |
| CHEMBL3426180 | — | — | 1 | 4.91 |
| CHEMBL3426249 | — | — | 1 | 4.90 |
| CHEMBL3426248 | — | — | 1 | 4.86 |
| CHEMBL3426250 | — | — | 1 | 4.69 |
| CHEMBL3426174 | — | — | 1 | 4.58 |
| CHEMBL109 | VALPROIC ACID | 4.0 | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3426173 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL3426170 | — | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL3426177 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL3426179 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL3426178 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL3426180 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL3426249 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3426248 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL3426250 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL3426174 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL109 | VALPROIC ACID | IC50 | = | 57400.0 | nM | 4.24 |