Assay Detail
ADMET
CHEMBL3428282
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human Jurkat T cells without TCR stimulation assessed as cell viability by ATPlite assay
14
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.61 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3298371 | — | — | 1 | 5.33 |
| CHEMBL3426309 | — | — | 1 | 4.92 |
| CHEMBL3426302 | — | — | 2 | 4.70 |
| CHEMBL3426305 | — | — | 2 | 4.70 |
| CHEMBL3426301 | — | — | 2 | 4.57 |
| CHEMBL3426304 | — | — | 1 | 4.54 |
| CHEMBL3426308 | — | — | 1 | 4.54 |
| CHEMBL3426303 | — | — | 2 | 4.48 |
| CHEMBL3426306 | — | — | 1 | 4.38 |
| CHEMBL3298374 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3298371 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3426309 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3426305 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3426302 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3426301 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3426304 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3426308 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3426305 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3426303 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3426306 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL3426302 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL3298374 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL3426301 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3426303 | — | IC50 | > | 50000.0 | nM | - |