Assay Detail
Toxicity
CHEMBL3428336
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Toxicity against APP expressing HEK cells assessed as reduction in cell viability after 48 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Small Molecules for Up-Regulating the Translation of Antiamyloidogenic Secretase, a Disintegrin and Metalloproteinase 10 (ADAM10), by Binding to the G-Quadruplex-Forming Sequence in the 5' Untranslated Region (UTR) of Its mRNA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.67 | 4.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3425903 | — | — | 1 | 4.97 |
| CHEMBL3425895 | — | — | 1 | 4.95 |
| CHEMBL3425894 | — | — | 1 | 4.91 |
| CHEMBL3425902 | — | — | 1 | 4.73 |
| CHEMBL3425888 | — | — | 1 | 4.67 |
| CHEMBL3425893 | — | — | 1 | 4.63 |
| CHEMBL3425884 | — | — | 1 | 4.59 |
| CHEMBL3425901 | — | — | 1 | 4.53 |
| CHEMBL3425896 | — | — | 1 | 4.44 |
| CHEMBL3425892 | — | — | 1 | 4.31 |
| CHEMBL3425886 | — | — | 1 | - |
| CHEMBL3425889 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3425903 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL3425895 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL3425894 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL3425902 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL3425888 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL3425893 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL3425884 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL3425901 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL3425896 | — | IC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL3425892 | — | IC50 | = | 49100.0 | nM | 4.31 |
| CHEMBL3425886 | — | IC50 | - | — | - | |
| CHEMBL3425889 | — | IC50 | > | 50000.0 | nM | - |