Assay Detail
Binding
CHEMBL3428360
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis
84
Total Activities
84
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO CGE |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CHEMBL3425388) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 84 | 7.70 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3426033 | — | — | 1 | 9.21 |
| CHEMBL3426037 | — | — | 1 | 9.19 |
| CHEMBL3426067 | — | — | 1 | 9.11 |
| CHEMBL3426064 | — | — | 1 | 9.05 |
| CHEMBL3426058 | — | — | 1 | 9.00 |
| CHEMBL3426066 | — | — | 1 | 8.96 |
| CHEMBL3426032 | — | — | 1 | 8.89 |
| CHEMBL3426039 | — | — | 1 | 8.85 |
| CHEMBL3426038 | — | — | 1 | 8.80 |
| CHEMBL3426035 | — | — | 1 | 8.80 |
| CHEMBL3426034 | — | — | 1 | 8.72 |
| CHEMBL3426040 | — | — | 1 | 8.60 |
| CHEMBL3426053 | — | — | 1 | 8.40 |
| CHEMBL3426057 | — | — | 1 | 8.40 |
| CHEMBL3426029 | — | — | 1 | 8.35 |
| CHEMBL3426036 | — | — | 1 | 8.28 |
| CHEMBL3426031 | — | — | 1 | 8.22 |
| CHEMBL3426027 | — | — | 1 | 8.21 |
| CHEMBL3426186 | — | — | 1 | 8.15 |
| CHEMBL3426063 | — | — | 1 | 8.15 |
| CHEMBL3426055 | — | — | 1 | 8.10 |
| CHEMBL3426059 | — | — | 1 | 8.10 |
| CHEMBL3426060 | — | — | 1 | 8.10 |
| CHEMBL3426052 | — | — | 1 | 8.05 |
| CHEMBL3426191 | — | — | 1 | 8.05 |
| CHEMBL3426056 | — | — | 1 | 8.00 |
| CHEMBL3426187 | — | — | 1 | 8.00 |
| CHEMBL3426028 | — | — | 1 | 7.96 |
| CHEMBL3426193 | — | — | 1 | 7.92 |
| CHEMBL3426093 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3426033 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL3426037 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL3426067 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL3426064 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3426058 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3426066 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3426032 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3426039 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3426038 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3426035 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3426034 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3426040 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3426053 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3426057 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3426029 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3426036 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL3426031 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3426027 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL3426186 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3426063 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3426055 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3426059 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3426060 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3426052 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3426191 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3426056 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3426187 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3426028 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3426193 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3426093 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3426188 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3426094 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3426085 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3426030 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3426189 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3426078 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3426068 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3426072 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3426077 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3426084 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3426090 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3426190 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3426086 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3426087 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3426071 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3426081 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3426075 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3426092 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3426083 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3426074 | — | IC50 | = | 31.0 | nM | 7.51 |