Assay Detail
Binding
CHEMBL3428554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His6-tagged UBLCP1 (unknown origin) expressed in Escherichia coli BL21 cells using pNPP as substrate at pH 6 at 25 degC by spectrophotometric analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BL21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ubiquitin-like domain-containing CTD phosphatase 1 (CHEMBL3317333) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.40 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3426913 | — | — | 1 | 6.30 |
| CHEMBL3425525 | — | — | 1 | 5.52 |
| CHEMBL3426911 | — | — | 1 | 5.38 |
| CHEMBL3426909 | — | — | 1 | 5.38 |
| CHEMBL3426907 | — | — | 1 | 5.36 |
| CHEMBL3426912 | — | — | 1 | 5.27 |
| CHEMBL3426910 | — | — | 1 | 5.08 |
| CHEMBL3426908 | — | — | 1 | 4.87 |
| CHEMBL424 | SALICYLIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3426913 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3425525 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3426911 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3426909 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3426907 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3426912 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3426910 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3426908 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL424 | SALICYLIC ACID | IC50 | = | 66000000.0 | nM | - |