Assay Detail
Binding
CHEMBL3428601
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human HPGDS expressed in Escherichia coli by isothermal titration calorimetry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hematopoietic prostaglandin D synthase (CHEMBL5879) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 7.06 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3425948 | — | — | 1 | 7.92 |
| CHEMBL1233897 | — | — | 1 | 7.70 |
| CHEMBL3425949 | — | — | 1 | 7.46 |
| CHEMBL3425951 | — | — | 1 | 6.68 |
| CHEMBL261777 | — | — | 1 | 6.52 |
| CHEMBL3425970 | — | — | 1 | 6.10 |
| CHEMBL406105 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3425948 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL1233897 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL3425949 | — | Kd | = | 35.0 | nM | 7.46 |
| CHEMBL3425951 | — | Kd | = | 210.0 | nM | 6.68 |
| CHEMBL261777 | — | Kd | = | 300.0 | nM | 6.52 |
| CHEMBL3425970 | — | Kd | = | 800.0 | nM | 6.10 |
| CHEMBL406105 | — | Kd | = | 140000.0 | nM | - |