Assay Detail
Binding
CHEMBL3428602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition HPGDS in human MEG01 cells assessed as reduction in PGD2 production incubated for 30 mins followed by stimulation with 5 uM ionomycin for 30 mins by enzyme immunoassay method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MEG-01 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hematopoietic prostaglandin D synthase (CHEMBL5879) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.98 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1233897 | — | — | 1 | 7.46 |
| CHEMBL3425949 | — | — | 1 | 7.13 |
| CHEMBL261777 | — | — | 1 | 6.96 |
| CHEMBL3425948 | — | — | 1 | 6.89 |
| CHEMBL3425951 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1233897 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3425949 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL261777 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3425948 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3425951 | — | EC50 | = | 350.0 | nM | 6.46 |