Assay Detail
Functional
CHEMBL3429079
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat mGluR8 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 8 (CHEMBL2718) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.84 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33567 | — | — | 1 | 6.96 |
| CHEMBL3427499 | — | — | 1 | 5.90 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33567 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3427499 | — | EC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 21470.0 | nM | 4.67 |