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Assay Detail

CHEMBL3429704

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity in HCV 2a JFH1 infected in HUH 7-lunet cells after 3 days by Dual-Glo luciferase assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Cell Type HUH 7-lunet
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379)
Type ORGANISM
Organism Hepacivirus hominis

Publication

Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action.
Mejdrová I, Chalupská D, Kögler M, Šála M, Plačková P, Baumlová A, Hřebabecký H, Procházková E, Dejmek M, Guillon R, Strunin D, Weber J, Lee G, Birkus G, Mertlíková-Kaiserová H, Boura E, Nencka R.
J Med Chem (2015) 58 : 3767 -3793
PubMed 25897704 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 4.91 6.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL236207 BETA-2'-C-METHYL-7-DEAZA-ADENOSINE 1 6.68
CHEMBL3426601 1 4.97
CHEMBL3426600 1 4.87
CHEMBL3426598 1 4.75
CHEMBL3426603 1 4.58
CHEMBL3426602 1 4.55
CHEMBL3426599 1 4.50
CHEMBL3426596 1 4.37
CHEMBL3426594 1 -
CHEMBL3426595 1 -
CHEMBL3426597 1 -
CHEMBL2397317 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL236207 BETA-2'-C-METHYL-7-DEAZA-ADENOSINE EC50 = 210.0 nM 6.68
CHEMBL3426601 EC50 = 10600.0 nM 4.97
CHEMBL3426600 EC50 = 13600.0 nM 4.87
CHEMBL3426598 EC50 = 17900.0 nM 4.75
CHEMBL3426603 EC50 = 26500.0 nM 4.58
CHEMBL3426602 EC50 = 27900.0 nM 4.55
CHEMBL3426599 EC50 = 31800.0 nM 4.50
CHEMBL3426596 EC50 = 42500.0 nM 4.37
CHEMBL3426594 EC50 > 44000.0 nM -
CHEMBL3426595 EC50 > 44000.0 nM -
CHEMBL3426597 EC50 > 44000.0 nM -
CHEMBL2397317 EC50 > 44000.0 nM -