Assay Detail
Binding
CHEMBL3429911
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Suppression of ER alpha in human MCF7 cells after 24 hrs by immunostaining analysis
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.47 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3427402 | — | — | 1 | 8.57 |
| CHEMBL195515 | — | — | 1 | 8.15 |
| CHEMBL3427399 | — | — | 1 | 8.15 |
| CHEMBL3427401 | — | — | 1 | 7.68 |
| CHEMBL3427398 | — | — | 1 | 7.52 |
| CHEMBL3427393 | — | — | 1 | 7.28 |
| CHEMBL3427405 | — | — | 1 | 7.26 |
| CHEMBL3427404 | — | — | 1 | 7.22 |
| CHEMBL3427415 | — | — | 1 | 7.00 |
| CHEMBL3427397 | — | — | 1 | 6.93 |
| CHEMBL3427395 | — | — | 1 | 6.75 |
| CHEMBL3427414 | — | — | 1 | 6.61 |
| CHEMBL3427501 | — | — | 1 | 6.60 |
| CHEMBL3427400 | — | — | 1 | 6.59 |
| CHEMBL3425530 | — | — | 1 | 6.50 |
| CHEMBL3427392 | — | — | 1 | 6.46 |
| CHEMBL3427390 | — | — | 1 | 6.33 |
| CHEMBL3427500 | — | — | 1 | 6.30 |
| CHEMBL3427407 | — | — | 1 | 6.29 |
| CHEMBL3427391 | — | — | 1 | 6.28 |
| CHEMBL3427394 | — | — | 1 | 6.18 |
| CHEMBL3427410 | — | — | 1 | 6.00 |
| CHEMBL3427385 | — | — | 1 | 5.93 |
| CHEMBL3427409 | — | — | 1 | 5.89 |
| CHEMBL3427389 | — | — | 1 | 5.89 |
| CHEMBL3427502 | — | — | 1 | 5.86 |
| CHEMBL3427403 | — | — | 1 | 5.84 |
| CHEMBL3427388 | — | — | 1 | 5.77 |
| CHEMBL3427396 | — | — | 1 | 5.65 |
| CHEMBL3427386 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3427402 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL195515 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3427399 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3427401 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3427398 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3427393 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3427405 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3427404 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3427415 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3427397 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL3427395 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL3427414 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL3427501 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL3427400 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL3425530 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3427392 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3427390 | — | IC50 | = | 471.0 | nM | 6.33 |
| CHEMBL3427500 | — | IC50 | = | 506.0 | nM | 6.30 |
| CHEMBL3427407 | — | IC50 | = | 509.0 | nM | 6.29 |
| CHEMBL3427391 | — | IC50 | = | 531.0 | nM | 6.28 |
| CHEMBL3427394 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3427410 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3427385 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL3427409 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3427389 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL3427502 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL3427403 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL3427388 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL3427396 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL3427386 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL3427412 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3427387 | — | IC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL3427408 | — | IC50 | = | 5840.0 | nM | 5.23 |
| CHEMBL3427413 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL3427406 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL3427411 | — | IC50 | > | 2150.0 | nM | - |
| CHEMBL33899 | — | IC50 | > | 1270.0 | nM | - |