Assay Detail
Binding
CHEMBL3429913
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Agonist activity at ER alpha in human MCF7 cells assessed as PR gene expression after 24 hrs by laser scanning imaging cytometer analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.99 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3427402 | — | — | 1 | 8.41 |
| CHEMBL3427401 | — | — | 1 | 7.57 |
| CHEMBL33899 | — | — | 1 | - |
| CHEMBL195515 | — | — | 1 | - |
| CHEMBL3427385 | — | — | 1 | - |
| CHEMBL3427414 | — | — | 1 | - |
| CHEMBL3427415 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3427402 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3427401 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL33899 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL195515 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3427385 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3427414 | — | IC50 | > | 3100.0 | nM | - |
| CHEMBL3427415 | — | IC50 | > | 3100.0 | nM | - |