Assay Detail
Functional
CHEMBL3430509
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells transfected with KCNQ1 / Kv1.7 / KvLQT1 and KCNE1/minK measured using IonWorks automated patch clamp platform
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) (CHEMBL2221347) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Prediction of Thorough QT study results using action potential simulations based on ion channel screens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.20 | 4.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1111 | AMBRISENTAN | 4.0 | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1111 | AMBRISENTAN | IC50 | = | 63095.73 | nM | 4.20 |