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Assay Detail

CHEMBL3431930

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Binding
SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, muscle isoform
ChEMBL ↗
476
Total Activities
476
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Tissue Muscle tissue
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carnitine O-palmitoyltransferase 1, muscle isoform (CHEMBL2216739) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Roche carnitine palmitoyltransferase modulator screening data (supplementary data associated with the publication CHEMBL2216752).

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 476 5.33 6.87

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3431544 — — 1 6.87
CHEMBL3431722 — — 1 6.84
CHEMBL3431461 — — 1 6.70
CHEMBL3431514 — — 1 6.65
CHEMBL3431634 — — 1 6.63
CHEMBL3431771 — — 1 6.59
CHEMBL3431764 — — 1 6.40
CHEMBL3431638 — — 1 6.37
CHEMBL3431685 — — 1 6.36
CHEMBL3431819 — — 1 6.35
CHEMBL3431728 — — 1 6.31
CHEMBL3431471 — — 1 6.30
CHEMBL3431766 — — 1 6.29
CHEMBL3431919 — — 1 6.28
CHEMBL3431752 — — 1 6.28
CHEMBL3431632 — — 1 6.27
CHEMBL3431622 — — 1 6.26
CHEMBL3431753 — — 1 6.22
CHEMBL3431821 — — 1 6.22
CHEMBL3431893 — — 1 6.22
CHEMBL3431621 — — 1 6.21
CHEMBL3431678 — — 1 6.21
CHEMBL3431886 — — 1 6.21
CHEMBL3431888 — — 1 6.21
CHEMBL3431532 — — 1 6.20
CHEMBL3431724 — — 1 6.20
CHEMBL3431470 — — 1 6.18
CHEMBL3431533 — — 1 6.17
CHEMBL3431926 — — 1 6.16
CHEMBL3431890 — — 1 6.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3431544 — IC50 = 133.95 nM 6.87
CHEMBL3431722 — IC50 = 145.3 nM 6.84
CHEMBL3431461 — IC50 = 202.0 nM 6.70
CHEMBL3431514 — IC50 = 226.05 nM 6.65
CHEMBL3431634 — IC50 = 235.3 nM 6.63
CHEMBL3431771 — IC50 = 259.2 nM 6.59
CHEMBL3431764 — IC50 = 399.5 nM 6.40
CHEMBL3431638 — IC50 = 423.3 nM 6.37
CHEMBL3431685 — IC50 = 438.6 nM 6.36
CHEMBL3431819 — IC50 = 447.0 nM 6.35
CHEMBL3431728 — IC50 = 490.7 nM 6.31
CHEMBL3431471 — IC50 = 504.35 nM 6.30
CHEMBL3431766 — IC50 = 511.9 nM 6.29
CHEMBL3431919 — IC50 = 527.9 nM 6.28
CHEMBL3431752 — IC50 = 530.7 nM 6.28
CHEMBL3431632 — IC50 = 535.2 nM 6.27
CHEMBL3431622 — IC50 = 552.9 nM 6.26
CHEMBL3431821 — IC50 = 601.8 nM 6.22
CHEMBL3431893 — IC50 = 597.9 nM 6.22
CHEMBL3431753 — IC50 = 601.1 nM 6.22
CHEMBL3431621 — IC50 = 613.8 nM 6.21
CHEMBL3431888 — IC50 = 622.2 nM 6.21
CHEMBL3431886 — IC50 = 619.9 nM 6.21
CHEMBL3431678 — IC50 = 618.1 nM 6.21
CHEMBL3431532 — IC50 = 628.3 nM 6.20
CHEMBL3431724 — IC50 = 634.1 nM 6.20
CHEMBL3431470 — IC50 = 661.2 nM 6.18
CHEMBL3431533 — IC50 = 674.25 nM 6.17
CHEMBL3431926 — IC50 = 685.5 nM 6.16
CHEMBL3431890 — IC50 = 703.4 nM 6.15
CHEMBL3431512 — IC50 = 741.3 nM 6.13
CHEMBL3431601 — IC50 = 747.9 nM 6.13
CHEMBL3431511 — IC50 = 750.4 nM 6.12
CHEMBL3431549 — IC50 = 754.7 nM 6.12
CHEMBL3431623 — IC50 = 792.4 nM 6.10
CHEMBL3431679 — IC50 = 797.3 nM 6.10
CHEMBL3431920 — IC50 = 820.3 nM 6.09
CHEMBL3431635 — IC50 = 827.2 nM 6.08
CHEMBL3431721 — IC50 = 843.7 nM 6.07
CHEMBL3431879 — IC50 = 857.4 nM 6.07
CHEMBL3431642 — IC50 = 920.0 nM 6.04
CHEMBL3431924 — IC50 = 914.4 nM 6.04
CHEMBL3431661 — IC50 = 932.4 nM 6.03
CHEMBL3431686 — IC50 = 949.7 nM 6.02
CHEMBL3431889 — IC50 = 954.9 nM 6.02
CHEMBL3431548 — IC50 = 989.0 nM 6.00
CHEMBL3431624 — IC50 = 991.7 nM 6.00
CHEMBL3431507 — IC50 = 1010.8 nM 6.00
CHEMBL3431677 — IC50 = 1080.6 nM 5.97
CHEMBL3431883 — IC50 = 1090.5 nM 5.96