Assay Detail
Functional
CHEMBL3436039
Review assay metadata, readout intent, target linkage, and publication context from the same page.
ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro
792
Total Activities
791
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania mexicana |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
St. Jude Leishmania screening dataset.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 792 | 5.45 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592105 | METHYLROSANILINE | -1.0 | 1 | 7.46 |
| CHEMBL547470 | DIHYDROEMETINE | — | 1 | 7.18 |
| CHEMBL50588 | EMETINE | 4.0 | 1 | 7.05 |
| CHEMBL535077 | — | — | 1 | 6.92 |
| CHEMBL532464 | — | — | 1 | 6.86 |
| CHEMBL581702 | — | — | 1 | 6.79 |
| CHEMBL535750 | — | — | 1 | 6.78 |
| CHEMBL526110 | — | — | 1 | 6.77 |
| CHEMBL588259 | — | — | 1 | 6.71 |
| CHEMBL587029 | — | — | 1 | 6.69 |
| CHEMBL525149 | — | — | 1 | 6.69 |
| CHEMBL581135 | — | — | 1 | 6.59 |
| CHEMBL529452 | — | — | 1 | 6.58 |
| CHEMBL580914 | — | — | 1 | 6.58 |
| CHEMBL123292 | CYCLOHEXIMIDE | 2.0 | 1 | 6.51 |
| CHEMBL588020 | — | — | 1 | 6.51 |
| CHEMBL530291 | — | — | 1 | 6.51 |
| CHEMBL587153 | — | — | 1 | 6.50 |
| CHEMBL423192 | ANISOMYCIN | — | 1 | 6.49 |
| CHEMBL593290 | — | — | 1 | 6.38 |
| CHEMBL546522 | — | — | 1 | 6.30 |
| CHEMBL532472 | — | — | 1 | 6.29 |
| CHEMBL587120 | — | — | 1 | 6.28 |
| CHEMBL532650 | — | — | 1 | 6.25 |
| CHEMBL580307 | — | — | 1 | 6.25 |
| CHEMBL547077 | — | — | 1 | 6.23 |
| CHEMBL468963 | GW779439X | — | 1 | 6.23 |
| CHEMBL536166 | — | — | 1 | 6.22 |
| CHEMBL528849 | — | — | 1 | 6.21 |
| CHEMBL170760 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592105 | METHYLROSANILINE | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL547470 | DIHYDROEMETINE | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL50588 | EMETINE | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL535077 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL532464 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL581702 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL535750 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL526110 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL588259 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL587029 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL525149 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL581135 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL580914 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL529452 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL588020 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL530291 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL123292 | CYCLOHEXIMIDE | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL587153 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL423192 | ANISOMYCIN | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL593290 | — | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL546522 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL532472 | — | IC50 | = | 518.0 | nM | 6.29 |
| CHEMBL587120 | — | IC50 | = | 525.0 | nM | 6.28 |
| CHEMBL580307 | — | IC50 | = | 559.0 | nM | 6.25 |
| CHEMBL532650 | — | IC50 | = | 565.0 | nM | 6.25 |
| CHEMBL547077 | — | IC50 | = | 592.0 | nM | 6.23 |
| CHEMBL468963 | GW779439X | IC50 | = | 583.0 | nM | 6.23 |
| CHEMBL536166 | — | IC50 | = | 607.0 | nM | 6.22 |
| CHEMBL170760 | — | IC50 | = | 619.0 | nM | 6.21 |
| CHEMBL528849 | — | IC50 | = | 617.0 | nM | 6.21 |
| CHEMBL580918 | — | IC50 | = | 633.0 | nM | 6.20 |
| CHEMBL593052 | — | IC50 | = | 642.0 | nM | 6.19 |
| CHEMBL526243 | — | IC50 | = | 699.0 | nM | 6.16 |
| CHEMBL535475 | — | IC50 | = | 685.0 | nM | 6.16 |
| CHEMBL536115 | — | IC50 | = | 714.0 | nM | 6.15 |
| CHEMBL353621 | — | IC50 | = | 724.0 | nM | 6.14 |
| CHEMBL529140 | — | IC50 | = | 744.0 | nM | 6.13 |
| CHEMBL531170 | — | IC50 | = | 776.0 | nM | 6.11 |
| CHEMBL124006 | — | IC50 | = | 829.0 | nM | 6.08 |
| CHEMBL587612 | — | IC50 | = | 873.0 | nM | 6.06 |
| CHEMBL526210 | — | IC50 | = | 873.0 | nM | 6.06 |
| CHEMBL528705 | — | IC50 | = | 891.0 | nM | 6.05 |
| CHEMBL586234 | — | IC50 | = | 899.0 | nM | 6.05 |
| CHEMBL588641 | — | IC50 | = | 911.0 | nM | 6.04 |
| CHEMBL529792 | — | IC50 | = | 903.0 | nM | 6.04 |
| CHEMBL532254 | — | IC50 | = | 1015.0 | nM | 5.99 |
| CHEMBL587090 | — | IC50 | = | 1055.0 | nM | 5.98 |
| CHEMBL582042 | — | IC50 | = | 1091.0 | nM | 5.96 |
| CHEMBL532699 | — | IC50 | = | 1152.0 | nM | 5.94 |
| CHEMBL537564 | — | IC50 | = | 1205.0 | nM | 5.92 |