Assay Detail
Functional
CHEMBL3436041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro
792
Total Activities
791
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania mexicana |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 2, facilitated glucose transporter member 1 (CHEMBL2535) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
St. Jude Leishmania screening dataset.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 792 | 5.43 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592105 | METHYLROSANILINE | -1.0 | 1 | 7.42 |
| CHEMBL547470 | DIHYDROEMETINE | — | 1 | 7.20 |
| CHEMBL50588 | EMETINE | 4.0 | 1 | 6.97 |
| CHEMBL535077 | — | — | 1 | 6.91 |
| CHEMBL535750 | — | — | 1 | 6.72 |
| CHEMBL532464 | — | — | 1 | 6.69 |
| CHEMBL526110 | — | — | 1 | 6.68 |
| CHEMBL581702 | — | — | 1 | 6.65 |
| CHEMBL123292 | CYCLOHEXIMIDE | 2.0 | 1 | 6.64 |
| CHEMBL587029 | — | — | 1 | 6.64 |
| CHEMBL530291 | — | — | 1 | 6.60 |
| CHEMBL525149 | — | — | 1 | 6.59 |
| CHEMBL588259 | — | — | 1 | 6.57 |
| CHEMBL580914 | — | — | 1 | 6.53 |
| CHEMBL423192 | ANISOMYCIN | — | 1 | 6.49 |
| CHEMBL587120 | — | — | 1 | 6.45 |
| CHEMBL581135 | — | — | 1 | 6.45 |
| CHEMBL587153 | — | — | 1 | 6.43 |
| CHEMBL593290 | — | — | 1 | 6.42 |
| CHEMBL526210 | — | — | 1 | 6.33 |
| CHEMBL532472 | — | — | 1 | 6.33 |
| CHEMBL546522 | — | — | 1 | 6.26 |
| CHEMBL593052 | — | — | 1 | 6.24 |
| CHEMBL468963 | GW779439X | — | 1 | 6.24 |
| CHEMBL536166 | — | — | 1 | 6.22 |
| CHEMBL580918 | — | — | 1 | 6.21 |
| CHEMBL580307 | — | — | 1 | 6.18 |
| CHEMBL535475 | — | — | 1 | 6.16 |
| CHEMBL547077 | — | — | 1 | 6.15 |
| CHEMBL532699 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592105 | METHYLROSANILINE | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL547470 | DIHYDROEMETINE | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL50588 | EMETINE | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL535077 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL535750 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL532464 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL526110 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL581702 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL123292 | CYCLOHEXIMIDE | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL587029 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL530291 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL525149 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL588259 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL580914 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL423192 | ANISOMYCIN | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL581135 | — | IC50 | = | 358.0 | nM | 6.45 |
| CHEMBL587120 | — | IC50 | = | 358.0 | nM | 6.45 |
| CHEMBL587153 | — | IC50 | = | 371.0 | nM | 6.43 |
| CHEMBL593290 | — | IC50 | = | 382.0 | nM | 6.42 |
| CHEMBL526210 | — | IC50 | = | 464.0 | nM | 6.33 |
| CHEMBL532472 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL546522 | — | IC50 | = | 547.0 | nM | 6.26 |
| CHEMBL593052 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL468963 | GW779439X | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL536166 | — | IC50 | = | 604.0 | nM | 6.22 |
| CHEMBL580918 | — | IC50 | = | 612.0 | nM | 6.21 |
| CHEMBL580307 | — | IC50 | = | 662.0 | nM | 6.18 |
| CHEMBL535475 | — | IC50 | = | 687.0 | nM | 6.16 |
| CHEMBL547077 | — | IC50 | = | 704.0 | nM | 6.15 |
| CHEMBL532699 | — | IC50 | = | 753.0 | nM | 6.12 |
| CHEMBL526243 | — | IC50 | = | 777.0 | nM | 6.11 |
| CHEMBL536115 | — | IC50 | = | 794.0 | nM | 6.10 |
| CHEMBL588020 | — | IC50 | = | 887.0 | nM | 6.05 |
| CHEMBL528849 | — | IC50 | = | 884.0 | nM | 6.05 |
| CHEMBL532650 | — | IC50 | = | 914.0 | nM | 6.04 |
| CHEMBL536112 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL587090 | — | IC50 | = | 953.0 | nM | 6.02 |
| CHEMBL582042 | — | IC50 | = | 953.0 | nM | 6.02 |
| CHEMBL170760 | — | IC50 | = | 1011.0 | nM | 6.00 |
| CHEMBL587612 | — | IC50 | = | 1004.0 | nM | 6.00 |
| CHEMBL581791 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL531170 | — | IC50 | = | 1021.0 | nM | 5.99 |
| CHEMBL353621 | — | IC50 | = | 1042.0 | nM | 5.98 |
| CHEMBL529140 | — | IC50 | = | 1052.0 | nM | 5.98 |
| CHEMBL548005 | — | IC50 | = | 1126.0 | nM | 5.95 |
| CHEMBL535741 | — | IC50 | = | 1138.0 | nM | 5.94 |
| CHEMBL546309 | — | IC50 | = | 1213.0 | nM | 5.92 |
| CHEMBL533883 | — | IC50 | = | 1315.0 | nM | 5.88 |
| CHEMBL529452 | — | IC50 | = | 1313.0 | nM | 5.88 |
| CHEMBL580580 | — | IC50 | = | 1383.0 | nM | 5.86 |