Assay Detail
ADMET
CHEMBL3529888
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of OATP1B3 (unknown origin) expressed in HEK293 cells assessed as reduction of [3H]estradiol-17beta-glucuronide uptake after 3 mins by beta-counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Solute carrier organic anion transporter family member 1B3 (CHEMBL1743121) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Interaction of silymarin flavonolignans with organic anion-transporting polypeptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.10 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431701 | SILYBIN A | 3.0 | 1 | 5.57 |
| CHEMBL592675 | SILYBIN B | — | 1 | 5.30 |
| CHEMBL4802105 | SILICRISTIN | 2.0 | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431701 | SILYBIN A | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL592675 | SILYBIN B | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4802105 | SILICRISTIN | IC50 | = | 36400.0 | nM | 4.44 |