Assay Detail
Binding
CHEMBL3530563
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumption
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Acetylenic linkers in lead compounds: a study of the stability of the propargyl-linked antifolates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.50 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3219804 | — | — | 1 | 7.92 |
| CHEMBL2335419 | — | — | 1 | 7.72 |
| CHEMBL3526249 | — | — | 1 | 7.68 |
| CHEMBL2335418 | — | — | 1 | 7.58 |
| CHEMBL2335417 | — | — | 1 | 7.58 |
| CHEMBL2335416 | — | — | 1 | 7.54 |
| CHEMBL3527096 | — | — | 1 | 7.35 |
| CHEMBL520358 | — | — | 1 | 7.21 |
| CHEMBL3527166 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3219804 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2335419 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3526249 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2335418 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2335417 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2335416 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3527096 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL520358 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3527166 | — | IC50 | = | 130.0 | nM | 6.89 |