Assay Detail
ADMET
CHEMBL3532077
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Inhibition of aldehyde oxidase in human liver cytosol assessed as production of oxozoniporide
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Cytosol |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 4.08 | 4.08 |
| Kinact | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1521 | ZALEPLON | 4.0 | 2 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1521 | ZALEPLON | Ki | = | 83000.0 | nM | 4.08 |
| CHEMBL1521 | ZALEPLON | Kinact | = | 0.063 | /min | - |