Assay Detail
ADMET
CHEMBL3533587
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Drug metabolism in rat intestinal microsomes assessed as formation of scutellarein-6,7-diglucuronide after 7 mins by HPLC/UV analysis
6
Total Activities
2
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Tissue | Intestine |
| Subcellular | Microsome |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Km | 2 | - | - |
| Vmax | 2 | - | - |
| Ki | 2 | 4.10 | 4.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487805 | SCUTELLARIN | — | 3 | 4.10 |
| CHEMBL3542370 | — | — | 3 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487805 | SCUTELLARIN | Ki | = | 79000.0 | nM | 4.10 |
| CHEMBL3542370 | — | Ki | = | 79200.0 | nM | 4.10 |
| CHEMBL487805 | SCUTELLARIN | Km | = | 349000.0 | nM | - |
| CHEMBL487805 | SCUTELLARIN | Vmax | = | 6.6 | nmol/min/mg | - |
| CHEMBL3542370 | — | Km | = | 41100.0 | nM | - |
| CHEMBL3542370 | — | Vmax | = | 1.23 | nmol/min/mg | - |