Assay Detail
ADMET
CHEMBL3534718
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Binding affinity to Wistar rat brain lipid by TRANSIL assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 16 | 5.40 | 6.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 6.74 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 6.49 |
| CHEMBL479 | THIORIDAZINE | 4.0 | 1 | 6.43 |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 6.41 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.11 |
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 1 | 6.00 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.81 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 5.49 |
| CHEMBL621 | TRAZODONE | 4.0 | 1 | 5.26 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 4.79 |
| CHEMBL108 | CARBAMAZEPINE | 4.0 | 1 | 4.62 |
| CHEMBL637 | VENLAFAXINE | 4.0 | 1 | 4.42 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 4.28 |
| CHEMBL1464 | WARFARIN | 4.0 | 1 | 4.09 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 4.05 |
| CHEMBL782 | TOLBUTAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71 | CHLORPROMAZINE | Kd | = | 184.0 | nM | 6.74 |
| CHEMBL41 | FLUOXETINE | Kd | = | 323.0 | nM | 6.49 |
| CHEMBL479 | THIORIDAZINE | Kd | = | 369.0 | nM | 6.43 |
| CHEMBL422 | TRIFLUOPERAZINE | Kd | = | 392.0 | nM | 6.41 |
| CHEMBL42 | CLOZAPINE | Kd | = | 775.0 | nM | 6.11 |
| CHEMBL629 | AMITRIPTYLINE | Kd | = | 1010.0 | nM | 6.00 |
| CHEMBL54 | HALOPERIDOL | Kd | = | 1560.0 | nM | 5.81 |
| CHEMBL12 | DIAZEPAM | Kd | = | 3240.0 | nM | 5.49 |
| CHEMBL621 | TRAZODONE | Kd | = | 5470.0 | nM | 5.26 |
| CHEMBL85 | RISPERIDONE | Kd | = | 16400.0 | nM | 4.79 |
| CHEMBL108 | CARBAMAZEPINE | Kd | = | 24200.0 | nM | 4.62 |
| CHEMBL637 | VENLAFAXINE | Kd | = | 38200.0 | nM | 4.42 |
| CHEMBL521 | IBUPROFEN | Kd | = | 52700.0 | nM | 4.28 |
| CHEMBL1464 | WARFARIN | Kd | = | 81400.0 | nM | 4.09 |
| CHEMBL86 | METOCLOPRAMIDE | Kd | = | 88900.0 | nM | 4.05 |
| CHEMBL782 | TOLBUTAMIDE | Kd | = | 646000.0 | nM | - |