Assay Detail
ADMET
CHEMBL3535132
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Competitive inhibition of rat recombinant CYP1A2 expressed in Escherichia coli assessed as inhibition of PHEN O-deethylation by dixon plot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Effect of albumin on human liver microsomal and recombinant CYP1A2 activities: impact on in vitro-in vivo extrapolation of drug clearance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.99 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3274190 | — | — | 1 | 5.33 |
| CHEMBL571449 | SODIUM LINOLATE | — | 1 | 4.87 |
| CHEMBL3527599 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3274190 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL571449 | SODIUM LINOLATE | Ki | = | 13600.0 | nM | 4.87 |
| CHEMBL3527599 | — | Ki | = | 16700.0 | nM | 4.78 |