Assay Detail
ADMET
CHEMBL3539670
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Induction of CYP2B6 mRNA expression in human donor hepatocytes after 48 hrs by real-time PCR method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quantitative prediction of CYP2B6 induction by estradiol during pregnancy: potential explanation for increased methadone clearance during pregnancy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.44 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | 4.0 | 1 | 6.01 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 5.72 |
| CHEMBL108 | CARBAMAZEPINE | 4.0 | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL135 | ESTRADIOL | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL108 | CARBAMAZEPINE | EC50 | = | 26000.0 | nM | 4.58 |