Assay Detail
ADMET
CHEMBL3541097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2C19 in human liver microsomes using omeprazole substrate by LC-MS/MS method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.97 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1484 | NICARDIPINE | 4.0 | 1 | 6.25 |
| CHEMBL45816 | MIBEFRADIL | 4.0 | 1 | 5.88 |
| CHEMBL1428 | NIMODIPINE | 4.0 | 1 | 5.66 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 5.27 |
| CHEMBL388590 | BENZBROMARONE | 4.0 | 1 | 4.74 |
| CHEMBL567 | PERPHENAZINE | 4.0 | 1 | 4.73 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 4.66 |
| CHEMBL809 | SERTRALINE | 4.0 | 1 | 4.65 |
| CHEMBL833 | TICLOPIDINE | 4.0 | 1 | 4.55 |
| CHEMBL1008 | BEPRIDIL | 4.0 | 1 | 4.49 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 4.47 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 4.34 |
| CHEMBL1017 | TELMISARTAN | 4.0 | 1 | - |
| CHEMBL161 | CEFTRIAXONE | 4.0 | 1 | - |
| CHEMBL30008 | FLUNARIZINE | 2.0 | 1 | - |
| CHEMBL682 | AMODIAQUINE | 4.0 | 1 | - |
| CHEMBL9 | NORFLOXACIN | 4.0 | 1 | - |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
| CHEMBL13 | METOPROLOL | 4.0 | 1 | - |
| CHEMBL1451 | TRIAMCINOLONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1484 | NICARDIPINE | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL45816 | MIBEFRADIL | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL1428 | NIMODIPINE | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL193 | NIFEDIPINE | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL388590 | BENZBROMARONE | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL567 | PERPHENAZINE | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL809 | SERTRALINE | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL833 | TICLOPIDINE | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL1008 | BEPRIDIL | IC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 34100.0 | nM | 4.47 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 45300.0 | nM | 4.34 |
| CHEMBL1017 | TELMISARTAN | IC50 | > | 50000.0 | nM | - |
| CHEMBL161 | CEFTRIAXONE | IC50 | > | 50000.0 | nM | - |
| CHEMBL30008 | FLUNARIZINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL682 | AMODIAQUINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL9 | NORFLOXACIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL54 | HALOPERIDOL | IC50 | > | 50000.0 | nM | - |
| CHEMBL13 | METOPROLOL | IC50 | > | 50000.0 | nM | - |
| CHEMBL1451 | TRIAMCINOLONE | IC50 | > | 50000.0 | nM | - |