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Assay Detail

CHEMBL3578472

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Antiproliferative activity against HEK293 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HEK293
Confidence 1 — Organism
Curated By Autocuration

Target

HEK293 (CHEMBL614818)
Type CELL-LINE
Organism Homo sapiens

Publication

Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods.
Minegishi H, Futamura Y, Fukashiro S, Muroi M, Kawatani M, Osada H, Nakamura H.
J Med Chem (2015) 58 : 4230 -4241
PubMed 25938266 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 7.86 8.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3578239 1 8.66
CHEMBL3578238 1 8.34
CHEMBL3578235 1 8.06
CHEMBL3578241 1 7.59
CHEMBL200726 1 7.27
CHEMBL3578230 1 7.25
CHEMBL3578231 1 -
CHEMBL175596 1 -
CHEMBL3578232 1 -
CHEMBL3578233 1 -
CHEMBL3578234 1 -
CHEMBL3578236 1 -
CHEMBL3578237 1 -
CHEMBL3578240 1 -
CHEMBL2323953 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3578239 IC50 = 2.2 nM 8.66
CHEMBL3578238 IC50 = 4.6 nM 8.34
CHEMBL3578235 IC50 = 8.8 nM 8.06
CHEMBL3578241 IC50 = 25.5 nM 7.59
CHEMBL200726 IC50 = 53.6 nM 7.27
CHEMBL3578230 IC50 = 55.6 nM 7.25
CHEMBL3578231 IC50 > 100.0 nM -
CHEMBL175596 IC50 > 100.0 nM -
CHEMBL3578232 IC50 > 100.0 nM -
CHEMBL3578233 IC50 > 100.0 nM -
CHEMBL3578234 IC50 > 100.0 nM -
CHEMBL3578236 IC50 > 100.0 nM -
CHEMBL3578237 IC50 > 100.0 nM -
CHEMBL3578240 IC50 > 100.0 nM -
CHEMBL2323953 IC50 > 100.0 nM -