Assay Detail
Binding
CHEMBL3579248
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay
10
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Growth hormone secretagogue receptor type 1 (CHEMBL4616) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rational design of dual peptides targeting ghrelin and Y2 receptors to regulate food intake and body weight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.36 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL500468 | GHRELIN | 3.0 | 2 | 8.64 |
| CHEMBL3578018 | — | — | 2 | 7.15 |
| CHEMBL3578016 | — | — | 2 | 7.11 |
| CHEMBL3578017 | — | — | 2 | 7.01 |
| CHEMBL3578015 | — | — | 2 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL500468 | GHRELIN | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL500468 | GHRELIN | IC50 | = | 2.291 | nM | 8.64 |
| CHEMBL3578018 | — | IC50 | = | 70.4 | nM | 7.15 |
| CHEMBL3578018 | — | IC50 | = | 70.79 | nM | 7.15 |
| CHEMBL3578016 | — | IC50 | = | 78.2 | nM | 7.11 |
| CHEMBL3578016 | — | IC50 | = | 77.62 | nM | 7.11 |
| CHEMBL3578017 | — | IC50 | = | 97.1 | nM | 7.01 |
| CHEMBL3578017 | — | IC50 | = | 97.72 | nM | 7.01 |
| CHEMBL3578015 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL3578015 | — | IC50 | = | 125.89 | nM | 6.90 |