Compound Detail
CHEMBL500468
GHRELIN 🧪 Phase III
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase III
CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O
Basic Information
| ChEMBL ID | CHEMBL500468 |
| Name | GHRELIN |
| Phase | Phase III |
| Structure Type | BOTH |
| InChI Key | JSRSZGUKOAXAJV-MXAPAKLGSA-N |
1
Targets
14
Activities
3
Assay Types
4
PK Parameters
16
Publications
3
Known Names
8
Indications
Molecular Properties
3314.8
MW (Da)
Drug Information
| Molecule Type | Protein |
| Chirality | Single Enantiomer |
Indications
Neoplasms Aging Brain Concussion Peripheral Arterial Disease Stroke Depressive Disorder, Major Diabetes Mellitus, Type 2 Obesity
Activity Summary
IC50 7 meas. best 9.85
EC50 6 meas. best 8.85
Ki 1 meas. best 9.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Growth hormone secretagogue receptor type 1 CHEMBL4616 | IC50 | 9.85 | 9.025 | 0.1 | 6 |
| Growth hormone secretagogue receptor type 1 CHEMBL4616 | Ki | 9.15 | 9.15 | 0.7 | 1 |
| Growth hormone secretagogue receptor type 1 CHEMBL4616 | EC50 | 8.85 | 8.625 | 1.4 | 6 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | - | - | Rattus norvegicus |
| CL | - | - | Rattus norvegicus |
| Cmax | - | - | Rattus norvegicus |
| F | - | % | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17371869 | 10.1074/jbc.m609796200 | Growth hormone secretagogue receptor type 1 | 18 |
| 22106937 | 10.1021/jm2007062 | Rattus norvegicus | 8 |
| 20133137 | 10.1016/j.bmc.2010.01.004 | Growth hormone secretagogue receptor type 1 | 4 |
| 23816043 | 10.1016/j.bmc.2013.06.006 | DU-145 | 4 |
| 22920150 | 10.1021/jm300414b | Growth hormone secretagogue receptor type 1 | 3 |
| 11459669 | 10.1016/s0960-894x(01)00324-9 | Growth hormone secretagogue receptor type 1 | 2 |
| 12646029 | 10.1021/jm020985q | Growth hormone secretagogue receptor type 1 | 2 |
| 18378446 | 10.1016/j.bmcl.2008.03.059 | Growth hormone secretagogue receptor type 1 | 2 |
| 25905598 | 10.1021/jm501702q | Growth hormone secretagogue receptor type 1 | 2 |
| 12646029 | 10.1021/jm020985q | Rattus norvegicus | 1 |
| 15780607 | 10.1016/j.bmcl.2005.02.042 | Growth hormone secretagogue receptor type 1 | 1 |
| 15780609 | 10.1016/j.bmcl.2005.02.040 | Growth hormone secretagogue receptor type 1 | 1 |
| 18295486 | 10.1016/j.bmcl.2008.02.021 | Growth hormone secretagogue receptor type 1 | 1 |
| 19323558 | 10.1021/jm8014519 | Growth hormone secretagogue receptor type 1 | 1 |
| 18554903 | 10.1016/j.bmcl.2008.05.100 | Growth hormone secretagogue receptor type 1 | 1 |
| 23816043 | 10.1016/j.bmc.2013.06.006 | Growth hormone secretagogue receptor type 1 | 1 |
Data from ChEMBL 36 via Core Engine