Assay Detail
Functional
CHEMBL945388
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at GHS receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Growth hormone secretagogue receptor type 1 (CHEMBL4616) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
(D)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: synthesis and incorporation into the growth hormone secretagogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.74 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460680 | — | — | 1 | 9.57 |
| CHEMBL471751 | — | — | 1 | 9.05 |
| CHEMBL500468 | GHRELIN | 3.0 | 1 | 8.85 |
| CHEMBL398372 | — | — | 1 | 8.72 |
| CHEMBL236038 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460680 | — | EC50 | = | 0.27 | nM | 9.57 |
| CHEMBL471751 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL500468 | GHRELIN | EC50 | = | 1.42 | nM | 8.85 |
| CHEMBL398372 | — | EC50 | = | 1.92 | nM | 8.72 |
| CHEMBL236038 | — | EC50 | = | 30.0 | nM | 7.52 |