Assay Detail
Functional
CHEMBL928778
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Growth hormone secretagogue receptor type 1 (CHEMBL4616) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 8.80 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL539929 | — | — | 1 | 9.47 |
| CHEMBL254765 | — | — | 1 | 9.38 |
| CHEMBL428592 | — | — | 1 | 9.35 |
| CHEMBL404354 | — | — | 1 | 9.29 |
| CHEMBL401827 | — | — | 1 | 9.21 |
| CHEMBL254973 | — | — | 1 | 9.14 |
| CHEMBL414394 | — | — | 1 | 8.98 |
| CHEMBL254565 | — | — | 1 | 8.96 |
| CHEMBL404355 | — | — | 1 | 8.93 |
| CHEMBL254363 | — | — | 1 | 8.90 |
| CHEMBL500468 | GHRELIN | 3.0 | 1 | 8.85 |
| CHEMBL254766 | — | — | 1 | 8.80 |
| CHEMBL254566 | — | — | 1 | 8.78 |
| CHEMBL253965 | — | — | 1 | 8.75 |
| CHEMBL398372 | — | — | 1 | 8.72 |
| CHEMBL254166 | — | — | 1 | 8.51 |
| CHEMBL254972 | — | — | 1 | 8.17 |
| CHEMBL254167 | — | — | 1 | 7.48 |
| CHEMBL253966 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL539929 | — | EC50 | = | 0.34 | nM | 9.47 |
| CHEMBL254765 | — | EC50 | = | 0.42 | nM | 9.38 |
| CHEMBL428592 | — | EC50 | = | 0.45 | nM | 9.35 |
| CHEMBL404354 | — | EC50 | = | 0.51 | nM | 9.29 |
| CHEMBL401827 | — | EC50 | = | 0.61 | nM | 9.21 |
| CHEMBL254973 | — | EC50 | = | 0.72 | nM | 9.14 |
| CHEMBL414394 | — | EC50 | = | 1.04 | nM | 8.98 |
| CHEMBL254565 | — | EC50 | = | 1.11 | nM | 8.96 |
| CHEMBL404355 | — | EC50 | = | 1.18 | nM | 8.93 |
| CHEMBL254363 | — | EC50 | = | 1.26 | nM | 8.90 |
| CHEMBL500468 | GHRELIN | EC50 | = | 1.41 | nM | 8.85 |
| CHEMBL254766 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL254566 | — | EC50 | = | 1.66 | nM | 8.78 |
| CHEMBL253965 | — | EC50 | = | 1.79 | nM | 8.75 |
| CHEMBL398372 | — | EC50 | = | 1.92 | nM | 8.72 |
| CHEMBL254166 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL254972 | — | EC50 | = | 6.75 | nM | 8.17 |
| CHEMBL254167 | — | EC50 | = | 33.2 | nM | 7.48 |
| CHEMBL253966 | — | EC50 | = | 34.0 | nM | 7.47 |