Assay Detail
Binding
CHEMBL685178
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Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Growth hormone secretagogue receptor type 1 (CHEMBL4616) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Spiro(indoline-3,4'-piperidine) growth hormone secretagogues as ghrelin mimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.18 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL500468 | GHRELIN | 3.0 | 1 | 9.60 |
| CHEMBL13817 | IBUTAMOREN | 2.0 | 1 | 9.20 |
| CHEMBL294324 | — | — | 1 | 8.09 |
| CHEMBL301259 | — | — | 1 | 7.44 |
| CHEMBL61292 | — | — | 1 | 6.89 |
| CHEMBL294408 | — | — | 1 | 6.68 |
| CHEMBL59572 | — | — | 1 | 6.23 |
| CHEMBL291333 | — | — | 1 | 6.08 |
| CHEMBL61663 | — | — | 1 | 6.05 |
| CHEMBL58758 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL500468 | GHRELIN | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL13817 | IBUTAMOREN | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL294324 | — | IC50 | = | 8.12 | nM | 8.09 |
| CHEMBL301259 | — | IC50 | = | 36.2 | nM | 7.44 |
| CHEMBL61292 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL294408 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL59572 | — | IC50 | = | 590.5 | nM | 6.23 |
| CHEMBL291333 | — | IC50 | = | 828.5 | nM | 6.08 |
| CHEMBL61663 | — | IC50 | = | 889.0 | nM | 6.05 |
| CHEMBL58758 | — | IC50 | = | 2670.0 | nM | 5.57 |