Assay Detail

CHEMBL3579414

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Functional

Antiviral activity against HIV1 by cell based MTT assay

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Human immunodeficiency virus 1 (CHEMBL378) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20.

Agniswamy J, Louis JM, Shen CH, Yashchuk S, Ghosh AK, Weber IT.
J Med Chem (2015) 58 : 5088 -5095
PubMed 26010498 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.62	8.62

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3577576	—	—	1	8.62

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3577576	—	IC50	=	2.4	nM	8.62