Assay Detail
Functional
CHEMBL3579615
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Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.30 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507237 | CUCURBITACIN B | — | 1 | 7.38 |
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 7.37 |
| CHEMBL455056 | CUCURBITACIN E | — | 1 | 7.26 |
| CHEMBL387737 | CUCURBITACIN I | — | 1 | 7.22 |
| CHEMBL301982 | CELASTROL | — | 1 | 6.82 |
| CHEMBL493646 | CUCURBITACIN D | — | 1 | 6.22 |
| CHEMBL2022241 | — | — | 1 | 6.14 |
| CHEMBL403003 | — | — | 1 | 5.29 |
| CHEMBL465226 | GEDUNIN | — | 1 | 4.96 |
| CHEMBL553851 | 23,24-DIHYDROCUCURBITACIN B | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507237 | CUCURBITACIN B | IC50 | = | 41.3 | nM | 7.38 |
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 42.7 | nM | 7.37 |
| CHEMBL455056 | CUCURBITACIN E | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL387737 | CUCURBITACIN I | IC50 | = | 60.7 | nM | 7.22 |
| CHEMBL301982 | CELASTROL | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL493646 | CUCURBITACIN D | IC50 | = | 598.0 | nM | 6.22 |
| CHEMBL2022241 | — | IC50 | = | 718.0 | nM | 6.14 |
| CHEMBL403003 | — | IC50 | = | 5130.0 | nM | 5.29 |
| CHEMBL465226 | GEDUNIN | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL553851 | 23,24-DIHYDROCUCURBITACIN B | IC50 | = | 46300.0 | nM | 4.33 |