Assay Detail
Binding
CHEMBL3579845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of antiTEV-tagged GCP2 extracellular portion (aa 44-750) (unknown origin) using folyl-di-L-glutamate as substrate by HPLC-based enzymatic assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of highly potent urea-based, exosite-binding inhibitors selective for glutamate carboxypeptidase II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 9.87 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3578202 | GOZETOTIDE | 4.0 | 1 | 10.74 |
| CHEMBL3309678 | — | — | 1 | 10.35 |
| CHEMBL3578199 | — | — | 1 | 10.31 |
| CHEMBL3578197 | — | — | 1 | 10.15 |
| CHEMBL3578200 | — | — | 1 | 9.96 |
| CHEMBL3311268 | — | — | 1 | 9.77 |
| CHEMBL47009 | — | — | 1 | 9.55 |
| CHEMBL596351 | — | — | 1 | 9.24 |
| CHEMBL3578198 | — | — | 1 | 8.80 |
| CHEMBL510924 | — | — | 1 | - |
| CHEMBL3578201 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3578202 | GOZETOTIDE | Ki | = | 0.018 | nM | 10.74 |
| CHEMBL3309678 | — | Ki | = | 0.045 | nM | 10.35 |
| CHEMBL3578199 | — | Ki | = | 0.049 | nM | 10.31 |
| CHEMBL3578197 | — | Ki | = | 0.071 | nM | 10.15 |
| CHEMBL3578200 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL3311268 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL47009 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL596351 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL3578198 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL510924 | — | Ki | = | 0.003 | nM | - |
| CHEMBL3578201 | — | Ki | = | 0.0086 | nM | - |