Compound Detail
CHEMBL3578202
GOZETOTIDE 💊 Approved Drug
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💊 Approved Drug
O=C(O)CCc1ccc(O)c(CN(CCN(CC(=O)O)Cc2cc(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)N[C@@H](CCC(=O)O)C(=O)O)C(=O)O)ccc2O)CC(=O)O)c1
Basic Information
| ChEMBL ID | CHEMBL3578202 |
| Name | GOZETOTIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | QJUIUFGOTBRHKP-LQJZCPKCSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
3
Known Names
1
Indications
1
Mechanisms
Molecular Properties
947.0
MW (Da)
1.55
ALogP
13
HBA
12
HBD
370.1
PSA (Ų)
0.04
QED
3
Ro5 Violations
35
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2020 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Diagnostic agent | - | - | ✓ | ✓ |
Indications
Prostatic Neoplasms
Activity Summary
Ki 3 meas. best 10.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate carboxypeptidase 2 CHEMBL1892 | Ki | 10.74 | 9.33 | 0.0 | 2 |
| Unchecked CHEMBL612545 | Ki | 7.89 | 7.89 | 13.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate carboxypeptidase 2 | Ki | = | 0.018 | nM | 10.74 | Inhibition of antiTEV-tagged GCP2 extracellular portion (aa 44-750) (unknown ori... | 25923815 |
| Glutamate carboxypeptidase 2 | Ki | = | 12.0 | nM | 7.92 | Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-... | 26878194 |
| Unchecked | Ki | = | 13.0 | nM | 7.89 | Inhibition of antiTEV-tagged GCP3 extracellular portion (aa 36-740) (unknown ori... | 25923815 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26878194 | 10.1021/acs.jmedchem.5b01210 | ADMET | 4 |
| 26878194 | 10.1021/acs.jmedchem.5b01210 | Glutamate carboxypeptidase 2 | 3 |
| 25923815 | 10.1021/acs.jmedchem.5b00278 | Unchecked | 2 |
| 26878194 | 10.1021/acs.jmedchem.5b01210 | No relevant target | 2 |
| 25923815 | 10.1021/acs.jmedchem.5b00278 | Glutamate carboxypeptidase 2 | 1 |
Data from ChEMBL 36 via Core Engine