Assay Detail
Binding
CHEMBL3579846
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Inhibition of antiTEV-tagged GCP3 extracellular portion (aa 36-740) (unknown origin) using folyl-di-L-glutamate as substrate by HPLC-based enzymatic assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design of highly potent urea-based, exosite-binding inhibitors selective for glutamate carboxypeptidase II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.45 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510924 | — | — | 1 | 8.60 |
| CHEMBL47009 | — | — | 1 | 8.57 |
| CHEMBL3311268 | — | — | 1 | 8.09 |
| CHEMBL3578202 | GOZETOTIDE | 4.0 | 1 | 7.89 |
| CHEMBL3309678 | — | — | 1 | 7.85 |
| CHEMBL3578201 | — | — | 1 | 7.80 |
| CHEMBL3578197 | — | — | 1 | 7.00 |
| CHEMBL596351 | — | — | 1 | 6.82 |
| CHEMBL3578199 | — | — | 1 | 6.68 |
| CHEMBL3578198 | — | — | 1 | 6.52 |
| CHEMBL3578200 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510924 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL47009 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL3311268 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL3578202 | GOZETOTIDE | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL3309678 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3578201 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL3578197 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL596351 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL3578199 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL3578198 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL3578200 | — | Ki | = | 730.0 | nM | 6.14 |