Assay Detail
Functional
CHEMBL3579983
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Cytotoxicity against cisplatin-resistant human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.62 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3578023 | — | — | 1 | 5.50 |
| CHEMBL3578022 | — | — | 1 | 5.42 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.46 |
| CHEMBL117 | CHRYSIN | — | 1 | 4.22 |
| CHEMBL77966 | RETUSIN | — | 1 | 4.08 |
| CHEMBL3578021 | — | — | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3578023 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL3578022 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL50 | QUERCETIN | IC50 | = | 34370.0 | nM | 4.46 |
| CHEMBL117 | CHRYSIN | IC50 | = | 60130.0 | nM | 4.22 |
| CHEMBL77966 | RETUSIN | IC50 | = | 82250.0 | nM | 4.08 |
| CHEMBL3578021 | — | IC50 | = | 98400.0 | nM | 4.01 |