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Assay Detail

CHEMBL3580016

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant full-length Fyn using Src substrate peptide after 15 mins incubation by MicroBeta liquid scintillation counting analysis
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase Fyn (CHEMBL1841)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors.
Tintori C, La Sala G, Vignaroli G, Botta L, Fallacara AL, Falchi F, Radi M, Zamperini C, Dreassi E, Dello Iacono L, Orioli D, Biamonti G, Garbelli M, Lossani A, Gasparrini F, Tuccinardi T, Laurenzana I, Angelucci A, Maga G, Schenone S, Brullo C, Musumeci F, Desogus A, Crespan E, Botta M.
J Med Chem (2015) 58 : 4590 -4609
PubMed 25923950 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 31 5.61 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3578214 1 7.16
CHEMBL3578215 1 7.02
CHEMBL3578213 1 6.44
CHEMBL3578218 1 6.06
CHEMBL3578212 1 6.05
CHEMBL3578219 1 6.00
CHEMBL3578210 1 5.94
CHEMBL3578204 1 5.85
CHEMBL3578216 1 5.83
CHEMBL3578221 1 5.79
CHEMBL3578224 1 5.68
CHEMBL3578225 1 5.65
CHEMBL3578217 1 5.47
CHEMBL411043 1 5.46
CHEMBL1775035 1 5.12
CHEMBL1775040 1 5.09
CHEMBL3578223 1 5.00
CHEMBL3578220 1 5.00
CHEMBL3578222 1 5.00
CHEMBL3578208 1 4.90
CHEMBL3578211 1 4.89
CHEMBL1775038 1 4.81
CHEMBL3578209 1 4.80
CHEMBL3578226 1 -
CHEMBL3578203 1 -
CHEMBL3578207 1 -
CHEMBL3578206 1 -
CHEMBL1775037 1 -
CHEMBL3394090 1 -
CHEMBL3394089 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3578214 Ki = 70.0 nM 7.16
CHEMBL3578215 Ki = 95.0 nM 7.02
CHEMBL3578213 Ki = 360.0 nM 6.44
CHEMBL3578218 Ki = 870.0 nM 6.06
CHEMBL3578212 Ki = 900.0 nM 6.05
CHEMBL3578219 Ki = 995.0 nM 6.00
CHEMBL3578210 Ki = 1150.0 nM 5.94
CHEMBL3578204 Ki = 1400.0 nM 5.85
CHEMBL3578216 Ki = 1485.0 nM 5.83
CHEMBL3578221 Ki = 1625.0 nM 5.79
CHEMBL3578224 Ki = 2100.0 nM 5.68
CHEMBL3578225 Ki = 2250.0 nM 5.65
CHEMBL3578217 Ki = 3350.0 nM 5.47
CHEMBL411043 Ki = 3500.0 nM 5.46
CHEMBL1775035 Ki = 7500.0 nM 5.12
CHEMBL1775040 Ki = 8150.0 nM 5.09
CHEMBL3578223 Ki = 10000.0 nM 5.00
CHEMBL3578220 Ki = 10000.0 nM 5.00
CHEMBL3578222 Ki = 10000.0 nM 5.00
CHEMBL3578208 Ki = 12500.0 nM 4.90
CHEMBL3578211 Ki = 13000.0 nM 4.89
CHEMBL1775038 Ki = 15500.0 nM 4.81
CHEMBL3578209 Ki = 16000.0 nM 4.80
CHEMBL3578226 Ki - -
CHEMBL3578203 Ki - -
CHEMBL3578207 Ki - -
CHEMBL3578206 Ki - -
CHEMBL1775037 Ki - -
CHEMBL3394090 Ki - -
CHEMBL3394089 Ki - -
CHEMBL3578205 Ki - -