Assay Detail
Binding
CHEMBL3580290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus (A/PR/8/34) (H1N1) RNA-dependent-RNA polymerase 6His-tagged-PA/GST-tagged-BP 1 interaction by ELISA
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
PA/PB1 (CHEMBL3137263) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 4.47 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3577821 | — | — | 1 | 5.96 |
| CHEMBL3288054 | — | — | 1 | 5.12 |
| CHEMBL89413 | — | — | 1 | 4.69 |
| CHEMBL3288048 | — | — | 1 | 4.59 |
| CHEMBL3577817 | — | — | 1 | 4.58 |
| CHEMBL3577823 | — | — | 1 | 4.55 |
| CHEMBL3288047 | — | — | 1 | 4.52 |
| CHEMBL3110337 | — | — | 1 | 4.50 |
| CHEMBL3110332 | — | — | 1 | 4.46 |
| CHEMBL3577824 | — | — | 1 | 4.46 |
| CHEMBL3577803 | — | — | 1 | 4.43 |
| CHEMBL3577802 | — | — | 1 | 4.40 |
| CHEMBL3577804 | — | — | 1 | 4.32 |
| CHEMBL3577806 | — | — | 1 | 4.12 |
| CHEMBL3577809 | — | — | 1 | 4.12 |
| CHEMBL3110352 | — | — | 1 | 4.04 |
| CHEMBL3577810 | — | — | 1 | 4.02 |
| CHEMBL3577813 | — | — | 1 | 4.00 |
| CHEMBL3577812 | — | — | 1 | 4.00 |
| CHEMBL3577799 | — | — | 1 | - |
| CHEMBL3577800 | — | — | 1 | - |
| CHEMBL3577801 | — | — | 1 | - |
| CHEMBL3577798 | — | — | 1 | - |
| CHEMBL3577797 | — | — | 1 | - |
| CHEMBL3577796 | — | — | 1 | - |
| CHEMBL284733 | DICLAZURIL | 2.0 | 1 | - |
| CHEMBL3577808 | — | — | 1 | - |
| CHEMBL3577805 | — | — | 1 | - |
| CHEMBL3577807 | — | — | 1 | - |
| CHEMBL3577822 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3577821 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3288054 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL89413 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL3288048 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL3577817 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3577823 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3288047 | — | IC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL3110337 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3110332 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3577824 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3577803 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3577802 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3577804 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL3577809 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL3577806 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL3110352 | — | IC50 | = | 90700.0 | nM | 4.04 |
| CHEMBL3577810 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL3577813 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3577812 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1643 | RIBAVIRIN | IC50 | - | — | - | |
| CHEMBL3577820 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL3577819 | — | IC50 | = | 158000.0 | nM | - |
| CHEMBL3577818 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL388590 | BENZBROMARONE | IC50 | - | — | - | |
| CHEMBL3577816 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3577815 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3577814 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3577811 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3577822 | — | IC50 | = | 128000.0 | nM | - |
| CHEMBL3577807 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3577805 | — | IC50 | = | 156000.0 | nM | - |
| CHEMBL3577808 | — | IC50 | = | 139000.0 | nM | - |
| CHEMBL284733 | DICLAZURIL | IC50 | - | — | - | |
| CHEMBL3577796 | — | IC50 | = | 153000.0 | nM | - |
| CHEMBL3577797 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3577798 | — | IC50 | = | 175000.0 | nM | - |
| CHEMBL3577801 | — | IC50 | = | 185000.0 | nM | - |
| CHEMBL3577800 | — | IC50 | = | 156000.0 | nM | - |
| CHEMBL3577799 | — | IC50 | = | 138000.0 | nM | - |