Assay Detail
Functional
CHEMBL3580291
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Influenza A virus (A/PR/8/34) (H1N1) infected in MDCK cells assessed as reduction in plaque formation after 48 hrs by plaque reduction assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 39 | 4.48 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3577824 | — | — | 1 | 6.00 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.10 |
| CHEMBL3288047 | — | — | 1 | 4.91 |
| CHEMBL89413 | — | — | 1 | 4.84 |
| CHEMBL3110337 | — | — | 1 | 4.75 |
| CHEMBL3577821 | — | — | 1 | 4.68 |
| CHEMBL3288054 | — | — | 1 | 4.62 |
| CHEMBL3577817 | — | — | 1 | 4.60 |
| CHEMBL3577807 | — | — | 1 | 4.55 |
| CHEMBL284733 | DICLAZURIL | 2.0 | 1 | 4.51 |
| CHEMBL388590 | BENZBROMARONE | 4.0 | 1 | 4.41 |
| CHEMBL3110332 | — | — | 1 | 4.40 |
| CHEMBL3577822 | — | — | 1 | 4.40 |
| CHEMBL3577811 | — | — | 1 | 4.39 |
| CHEMBL3577820 | — | — | 1 | 4.38 |
| CHEMBL3577802 | — | — | 1 | 4.33 |
| CHEMBL3577823 | — | — | 1 | 4.31 |
| CHEMBL3577805 | — | — | 1 | 4.23 |
| CHEMBL3288048 | — | — | 1 | 4.12 |
| CHEMBL3577815 | — | — | 1 | 4.07 |
| CHEMBL3577803 | — | — | 1 | 4.00 |
| CHEMBL3577808 | — | — | 1 | 4.00 |
| CHEMBL3577812 | — | — | 1 | 4.00 |
| CHEMBL3577804 | — | — | 1 | 4.00 |
| CHEMBL3577806 | — | — | 1 | - |
| CHEMBL3577798 | — | — | 1 | - |
| CHEMBL3577797 | — | — | 1 | - |
| CHEMBL3577819 | — | — | 1 | - |
| CHEMBL3577818 | — | — | 1 | - |
| CHEMBL3577816 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3577824 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3288047 | — | EC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL89413 | — | EC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL3110337 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3577821 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3288054 | — | EC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL3577817 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3577807 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL284733 | DICLAZURIL | EC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL388590 | BENZBROMARONE | EC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL3110332 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3577822 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3577811 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL3577820 | — | EC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL3577802 | — | EC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL3577823 | — | EC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL3577805 | — | EC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL3288048 | — | EC50 | = | 75500.0 | nM | 4.12 |
| CHEMBL3577815 | — | EC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL3577808 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3577812 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3577804 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3577803 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3110352 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3577799 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3577800 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3577801 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3577809 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3577810 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3577796 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3577813 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3577814 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3577816 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3577818 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3577819 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3577797 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3577798 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3577806 | — | EC50 | > | 100000.0 | nM | - |