Assay Detail
Functional
CHEMBL3580298
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Antiviral activity against Influenza A virus A/Wisconsin/67/05 (H3N2) assessed as reduction in plaque formation after 48 hrs by plaque reduction assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/Wisconsin/67/2005(H3N2)) |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.77 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3577821 | — | — | 1 | 5.16 |
| CHEMBL3577823 | — | — | 1 | 4.85 |
| CHEMBL3577817 | — | — | 1 | 4.62 |
| CHEMBL3577802 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3577821 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3577823 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3577817 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3577802 | — | EC50 | = | 37000.0 | nM | 4.43 |