Assay Detail
Functional
CHEMBL3582520
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytoprotective activity against H2O2-induced cytotoxicity in human EAhy926 cells pre-incubated for 24 hrs before H2O2 challenge for 12 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EA.hy 926 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel trimethylpyrazine-2-carbonyloxy-cinnamic acids as potent cardiovascular agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 4.56 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3580735 | — | — | 1 | 5.77 |
| CHEMBL3580734 | — | — | 1 | 5.66 |
| CHEMBL3580724 | — | — | 1 | 5.06 |
| CHEMBL17347 | ETHYL CAFFEATE | — | 1 | 4.94 |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | 4.90 |
| CHEMBL3580733 | — | — | 1 | 4.67 |
| CHEMBL3580718 | — | — | 1 | 4.62 |
| CHEMBL233295 | ISOFERULIC ACID | — | 1 | 4.53 |
| CHEMBL3580725 | — | — | 1 | 4.52 |
| CHEMBL3580717 | — | — | 1 | 4.46 |
| CHEMBL3580732 | — | — | 1 | 4.46 |
| CHEMBL3580727 | — | — | 1 | 4.44 |
| CHEMBL3580720 | — | — | 1 | 4.43 |
| CHEMBL3580716 | — | — | 1 | 4.42 |
| CHEMBL3580723 | — | — | 1 | 4.41 |
| CHEMBL3580730 | — | — | 1 | 4.31 |
| CHEMBL134342 | THIOCTIC ACID | — | 1 | 4.17 |
| CHEMBL3580736 | — | — | 1 | 4.17 |
| CHEMBL3580722 | — | — | 1 | 4.16 |
| CHEMBL303697 | LIGUSTRAZINE | — | 1 | 4.08 |
| CHEMBL3580719 | — | — | 1 | 4.03 |
| CHEMBL3580726 | — | — | 1 | 4.02 |
| CHEMBL3580728 | — | — | 1 | - |
| CHEMBL3580729 | — | — | 1 | - |
| CHEMBL3580731 | — | — | 1 | - |
| CHEMBL3580721 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3580735 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3580734 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3580724 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL17347 | ETHYL CAFFEATE | EC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL145 | CAFFEIC ACID | EC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL3580733 | — | EC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL3580718 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL233295 | ISOFERULIC ACID | EC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL3580725 | — | EC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL3580717 | — | EC50 | = | 34900.0 | nM | 4.46 |
| CHEMBL3580732 | — | EC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL3580727 | — | EC50 | = | 36100.0 | nM | 4.44 |
| CHEMBL3580720 | — | EC50 | = | 36700.0 | nM | 4.43 |
| CHEMBL3580716 | — | EC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL3580723 | — | EC50 | = | 38600.0 | nM | 4.41 |
| CHEMBL3580730 | — | EC50 | = | 48600.0 | nM | 4.31 |
| CHEMBL134342 | THIOCTIC ACID | EC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL3580736 | — | EC50 | = | 67200.0 | nM | 4.17 |
| CHEMBL3580722 | — | EC50 | = | 69400.0 | nM | 4.16 |
| CHEMBL303697 | LIGUSTRAZINE | EC50 | = | 83400.0 | nM | 4.08 |
| CHEMBL3580719 | — | EC50 | = | 92600.0 | nM | 4.03 |
| CHEMBL3580726 | — | EC50 | = | 95200.0 | nM | 4.02 |
| CHEMBL3580728 | — | EC50 | = | 115300.0 | nM | - |
| CHEMBL3580729 | — | EC50 | = | 137700.0 | nM | - |
| CHEMBL3580731 | — | EC50 | = | 104600.0 | nM | - |
| CHEMBL3580721 | — | EC50 | = | 108400.0 | nM | - |