Assay Detail
Binding
CHEMBL3582613
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SIRT2 (unknown origin) by Flour-de-Lys fluorescent biochemical assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and Evaluation of 3-(Benzylthio)benzamide Derivatives as Potent and Selective SIRT2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.25 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3580805 | — | — | 1 | 5.62 |
| CHEMBL3580803 | — | — | 1 | 5.54 |
| CHEMBL3580796 | — | — | 1 | 5.33 |
| CHEMBL3237032 | — | — | 1 | 5.21 |
| CHEMBL3580802 | — | — | 1 | 5.17 |
| CHEMBL3580806 | — | — | 1 | 5.15 |
| CHEMBL3580804 | — | — | 1 | 5.08 |
| CHEMBL1797749 | — | — | 1 | 4.90 |
| CHEMBL3580810 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3580805 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3580803 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3580796 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3237032 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3580802 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3580806 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3580804 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL1797749 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3580810 | — | IC50 | - | — | - |