Assay Detail
Functional
CHEMBL3583017
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against PAR2 in human HT29 cells assessed as inhibition of UTP-induced Ca2+ responses pre-incubated for 30 mins before UTP stimulation by FLIPR assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of the PAR-2 Signaling Pathway May Treat Pain and Inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.69 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3582249 | — | — | 1 | 5.36 |
| CHEMBL3582248 | — | — | 1 | 4.01 |
| CHEMBL3582251 | — | — | 1 | - |
| CHEMBL3582250 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3582249 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3582248 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL3582251 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3582250 | — | IC50 | > | 500.0 | nM | - |