Assay Detail
Binding
CHEMBL3583018
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Binding affinity to His-tagged PD-L1 (unknown origin) assessed as inhibition of interaction with PD1 preincubated for 15 mins followed by PD1 addition measured after 15 mins by HTRF assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of the PD-1/PD-L1 Pathway Can Mobilize the Immune System: An Innovative Potential Therapy for Cancer and Chronic Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.64 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3582257 | — | — | 1 | 8.22 |
| CHEMBL3582256 | — | — | 1 | 8.22 |
| CHEMBL3582254 | — | — | 1 | 8.22 |
| CHEMBL3582252 | — | — | 1 | 8.22 |
| CHEMBL3582253 | — | — | 1 | 6.96 |
| CHEMBL3582255 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3582257 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3582256 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3582254 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3582252 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3582253 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3582255 | — | IC50 | = | 1010.0 | nM | 6.00 |