Assay Detail
ADMET
CHEMBL3583058
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Cytotoxicity against HEK293A cells transfected with alpha-1A adrenergic receptor assessed as cell viability by sulforhodamine B assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293-A |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Quinazoline-Based Fluorescent Probes to α1-Adrenergic Receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.74 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3582270 | — | — | 1 | 4.92 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 4.72 |
| CHEMBL3582272 | — | — | 1 | 4.58 |
| CHEMBL3582271 | — | — | 1 | - |
| CHEMBL3582269 | — | — | 1 | - |
| CHEMBL3582268 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3582270 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL707 | DOXAZOSIN | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3582272 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3582271 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3582269 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3582268 | — | IC50 | > | 100000.0 | nM | - |