Assay Detail
Functional
CHEMBL3583198
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 3B infected in human HeLa-CD4-LTR-beta-gal cells assessed as inhibition of viral replication by SpectraMax GEMINI-XS plate reader analysis
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 55 | 5.30 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 1 | 7.85 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 7.63 |
| CHEMBL3582044 | — | — | 1 | 6.24 |
| CHEMBL3582058 | — | — | 1 | 6.06 |
| CHEMBL3582038 | — | — | 1 | 6.00 |
| CHEMBL3582039 | — | — | 1 | 5.82 |
| CHEMBL2236598 | RDS-1624 | — | 1 | 5.77 |
| CHEMBL3582057 | — | — | 1 | 5.58 |
| CHEMBL2236589 | 20, RDS-2163 | — | 1 | 5.58 |
| CHEMBL3582080 | — | — | 1 | 5.32 |
| CHEMBL2236601 | RDS-1984 | — | 1 | 5.09 |
| CHEMBL2236602 | — | — | 1 | 5.07 |
| CHEMBL2236588 | — | — | 1 | 5.03 |
| CHEMBL3582046 | — | — | 1 | 5.01 |
| CHEMBL3582052 | — | — | 1 | 5.00 |
| CHEMBL3582055 | — | — | 1 | 4.96 |
| CHEMBL3582062 | — | — | 1 | 4.86 |
| CHEMBL3582056 | — | — | 1 | 4.81 |
| CHEMBL3582064 | — | — | 1 | 4.79 |
| CHEMBL3582074 | — | — | 1 | 4.77 |
| CHEMBL3582053 | — | — | 1 | 4.76 |
| CHEMBL3582070 | — | — | 1 | 4.63 |
| CHEMBL2236599 | — | — | 1 | 4.55 |
| CHEMBL3582049 | — | — | 1 | 4.52 |
| CHEMBL3582041 | — | — | 1 | 4.51 |
| CHEMBL3582047 | — | — | 1 | 4.49 |
| CHEMBL3582072 | — | — | 1 | 4.30 |
| CHEMBL3582071 | — | — | 1 | - |
| CHEMBL3582061 | — | — | 1 | - |
| CHEMBL3582069 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | EC50 | = | 14.2 | nM | 7.85 |
| CHEMBL254316 | RALTEGRAVIR | EC50 | = | 23.6 | nM | 7.63 |
| CHEMBL3582044 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3582058 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3582038 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3582039 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2236598 | RDS-1624 | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3582057 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2236589 | 20, RDS-2163 | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3582080 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2236601 | RDS-1984 | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL2236602 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL2236588 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL3582046 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL3582052 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3582055 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3582062 | — | EC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL3582056 | — | EC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL3582064 | — | EC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL3582074 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3582053 | — | EC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL3582070 | — | EC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL2236599 | — | EC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL3582049 | — | EC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL3582041 | — | EC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL3582047 | — | EC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL3582072 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3582054 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582059 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL2236603 | RDS-2161 | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582068 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582051 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582050 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582048 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL2236600 | — | EC50 | < | 200.0 | nM | - |
| CHEMBL3582045 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582040 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582043 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582042 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582082 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582081 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582079 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582078 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582077 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582076 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582075 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582073 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582069 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582061 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3582071 | — | EC50 | > | 50000.0 | nM | - |