Assay Detail
Binding
CHEMBL3583583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ACE (unknown origin) using 3-Hydroxybutylyl-Gly-Gly-Gly substrate assessed as reduction in 3-Hyroxybutylic acid generation incubated for 1 hr by colorimetric assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Top-down Targeted Metabolomics Reveals a Sulfur-Containing Metabolite with Inhibitory Activity against Angiotensin-Converting Enzyme in Asparagus officinalis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.12 | 8.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 8.79 |
| CHEMBL310578 | — | — | 1 | 4.84 |
| CHEMBL3581907 | — | — | 1 | 4.73 |
| CHEMBL3581910 | — | — | 1 | - |
| CHEMBL274323 | ASPARTIC ACID | 3.0 | 1 | - |
| CHEMBL1485 | ARGININE | 3.0 | 1 | - |
| CHEMBL212301 | — | — | 1 | - |
| CHEMBL3581909 | — | — | 1 | - |
| CHEMBL3581908 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 1.61 | nM | 8.79 |
| CHEMBL310578 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL3581907 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL3581910 | — | IC50 | - | — | - | |
| CHEMBL274323 | ASPARTIC ACID | IC50 | - | — | - | |
| CHEMBL1485 | ARGININE | IC50 | - | — | - | |
| CHEMBL212301 | — | IC50 | - | — | - | |
| CHEMBL3581909 | — | IC50 | = | 347000.0 | nM | - |
| CHEMBL3581908 | — | IC50 | = | 113000.0 | nM | - |