Assay Detail
Functional
CHEMBL3583595
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Antileishmanial activity against promastigote stage of Leishmania infantum MHOM/BR/1972/LD assessed as reduction of cell viability after 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-parasitic Guanidine and Pyrimidine Alkaloids from the Marine Sponge Monanchora arbuscula.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.50 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3581920 | — | — | 1 | 5.70 |
| CHEMBL1077544 | BATZELLADINE L | — | 1 | 5.70 |
| CHEMBL1077542 | NORBATZELLADINE L | — | 1 | 5.70 |
| CHEMBL3581919 | — | — | 1 | 5.70 |
| CHEMBL3581921 | — | — | 1 | 5.40 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.80 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3581920 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1077544 | BATZELLADINE L | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1077542 | NORBATZELLADINE L | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3581919 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3581921 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | - | — | - |