Assay Detail
Functional
CHEMBL3583702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human SKHEP1 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-HEP1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Activity Relationships of Neplanocin A Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.32 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL154745 | — | — | 1 | 6.14 |
| CHEMBL64718 | FLUORO-NEPLANOCIN A | — | 1 | 6.10 |
| CHEMBL200935 | DEAZANEPLANOCIN A | — | 1 | 5.93 |
| CHEMBL3580896 | — | — | 1 | 5.86 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.67 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.55 |
| CHEMBL8771 | NEOPLANOCIN A | — | 1 | 5.35 |
| CHEMBL310547 | — | — | 1 | 5.21 |
| CHEMBL3580900 | — | — | 1 | 5.09 |
| CHEMBL80375 | — | — | 1 | 4.54 |
| CHEMBL3580899 | — | — | 1 | 4.38 |
| CHEMBL3580894 | — | — | 1 | 4.00 |
| CHEMBL3580895 | — | — | 1 | - |
| CHEMBL3580897 | — | — | 1 | - |
| CHEMBL3580898 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL154745 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL64718 | FLUORO-NEPLANOCIN A | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL200935 | DEAZANEPLANOCIN A | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL3580896 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL803 | CYTARABINE | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL8771 | NEOPLANOCIN A | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL310547 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL3580900 | — | IC50 | = | 8070.0 | nM | 5.09 |
| CHEMBL80375 | — | IC50 | = | 28890.0 | nM | 4.54 |
| CHEMBL3580899 | — | IC50 | = | 42090.0 | nM | 4.38 |
| CHEMBL3580894 | — | IC50 | = | 99180.0 | nM | 4.00 |
| CHEMBL3580895 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3580897 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3580898 | — | IC50 | > | 100000.0 | nM | - |